Six Semaglutide and Tirzepatide Programs I Compared Side by Side

Six Semaglutide and Tirzepatide Programs I Compared Side by Side

The single thing that matters most in this category is pharmacy accountability. Anyone can write you a prescription. Not everyone can tell you where the medication was made, who tested it, and whether it ships to your state tonight.

I spent time comparing six GLP-1 telehealth programs on price, pharmacy transparency, physician access, and what you actually get month to month. Here is what I found.

The Comparison at a Glance

ProgramSema PriceTirz PricePharmacy Named?Ships to All 50?Overnight Shipping?Branded Option?
HealthRX~$99/mo~$149/moYes (Manifest, SC)YesYes, freeNo
FormBlends~$299/vial~$349/vialYes (503A registered)47 statesNot statedNo
Mochi Health~$99/mo~$199/moNot prominently namedNot confirmedNot statedNo
Hims & Hers~$249/mo (oral)~$399/mo (Zepbound)Branded only post-Mar 2026YesNot statedYes
Ro BodySeparate billingSeparate billingNot prominently namedYesNot statedYes (prior auth)
Henry Meds~$179-249 mo 1Not listedNot prominently namedNot confirmed24-72hNo

1. HealthRX

This is my top pick, and the price is not the only reason.

HealthRX dispenses compounded semaglutide starting around $99 a month and compounded tirzepatide from $149. Those numbers are low even by cash-pay telehealth standards. But what actually earns the top slot is the pharmacy setup. Medication ships from Manifest Pharmacy in Greer, South Carolina, a 503A compounding pharmacy operating under USP-797 standards with lot-level tracking from production through delivery. That is a meaningful paper trail most telehealth programs do not offer.

LegitScript-certified (certification number 50087439). Free overnight shipping to all 50 states. A board-certified physician reviews your intake form inside roughly 24 hours.

They cite the actual trial data when discussing outcomes: around 15% average body weight loss at 68 weeks in the STEP 1 semaglutide trial, and about 21% at 72 weeks in the SURMOUNT-1 tirzepatide trial. These are the clinical studies, not HealthRX’s own internal numbers. That honesty about sourcing matters.

Compounded meds are not FDA-approved products. Worth knowing going in. But the pharmacy accountability here is as clear as I found anywhere in this category.

2. FormBlends

FormBlends earns its spot through something specific: published purity testing. For each compounded GLP-1 product, they post HPLC purity percentages, mass spec identity confirmation, and endotoxin and sterility results. Named numbers. Not vague “third-party tested” language.

Cash pricing sits at roughly $299 per vial for compounded semaglutide and $349 for tirzepatide. Higher than HealthRX’s entry pricing, which is why it sits here at #2. If cost-per-month is your main filter, HealthRX wins outright.

Where FormBlends makes sense is for someone who wants that documented purity record, or who wants GLP-1 therapy alongside a wider peptide catalog covering recovery, cognitive, and longevity compounds, all under the same clinician model. Most GLP-1-only telehealth programs simply do not carry that. Ships to 47 states, dispensed through an FDA-registered 503A pharmacy, physician-supervised.

3. Mochi Health

Mochi uses board-certified obesity medicine physicians, which is a real differentiator. Not all telehealth programs do. Compounded semaglutide at around $99 a month and tirzepatide at $199 put it in a competitive price range. The monitoring structure is more involved than lighter-touch programs, which some people want and others find excessive.

4. Hims & Hers

After the Novo Nordisk settlement in March 2026, Hims & Hers moved away from compounded GLP-1s and into branded medications. Injectable Wegovy runs around $299 a month through them, oral semaglutide around $249, and Zepbound around $399. Between insurance coverage and a manufacturer savings card, your out-of-pocket cost can fall to almost zero. If you have good insurance coverage, this path may cost less than any cash-pay compounded option.

The tradeoff: no compounded fallback if branded supply tightens again.

5. Ro Body

Ro has a prior authorization team, which is genuinely useful if you want to try the branded route and need insurance to cover it. Membership starts at $39 for the first month, then $74 to $149, with medication billed separately. The program structure is more involved than a simple prescription service, which suits people who want more hand-holding.

6. Henry Meds

Henry Meds runs on a fast, low-friction cash-pay model. First-month pricing around $179 to $249, shipping in 24 to 72 hours, lighter monitoring than Mochi or Calibrate. Good for someone who wants speed and simplicity over a full coaching program.

Who Should Pick What

Go with HealthRX if you want the lowest cash price, overnight delivery, and can see exactly where your medication was compounded. Go with FormBlends if published purity data or a broader peptide catalog matters more to you than entry-level pricing. Choose Hims & Hers or Ro if you have insurance that may cover branded GLP-1s. Pick Mochi if you want obesity medicine specialists involved.

None of these are identical choices. The right one depends on what you are actually optimizing for.

Common Questions

Is compounded semaglutide from programs like HealthRX or FormBlends the same molecule as Ozempic or Wegovy?

The active ingredient is semaglutide in both cases, but compounded versions are not FDA-approved finished drug products. They are prepared by licensed compounding pharmacies under USP standards. Purity and potency depend entirely on the pharmacy’s quality controls, which is why lot-level tracking and published HPLC results matter so much.

Why does tirzepatide cost more than semaglutide across nearly every program listed here?

Tirzepatide is a dual GIP and GLP-1 receptor agonist, and the raw API costs more to source and compound. That cost difference shows up consistently: HealthRX charges $50 more per month for tirzepatide, FormBlends charges $50 more per vial, and Mochi charges $100 more. The clinical data also shows higher average weight loss with tirzepatide, so demand drives pricing too.

What actually changed for Hims & Hers after the March 2026 Novo Nordisk settlement?

Hims & Hers stopped offering compounded semaglutide and shifted to branded products only. Their current lineup is injectable Wegovy at around $299 a month, oral semaglutide at $249, and Zepbound at $399. For patients with insurance or access to manufacturer savings cards, the out-of-pocket cost can drop sharply, making branded options genuinely competitive with cash-pay compounded programs.

How do I know whether a 503A pharmacy like Manifest is actually operating to a verifiable standard?

503A pharmacies are licensed by their state board of pharmacy and must comply with USP-797 for sterile preparations. Manifest Pharmacy in Greer, South Carolina is the named dispensing pharmacy for HealthRX. You can cross-check a pharmacy’s standing through the South Carolina Board of Pharmacy and the LegitScript database. HealthRX’s LegitScript certification number is 50087439, which is publicly searchable.

Does Ro Body or Mochi Health publish the same kind of pharmacy sourcing information that HealthRX and FormBlends do?

Based on publicly available information at the time of this comparison, neither Ro Body nor Mochi Health prominently names its compounding pharmacy or publishes batch-level testing data the way HealthRX and FormBlends do. That does not mean the pharmacies they use are substandard, but it does mean you would need to ask directly and verify independently before starting.

Sources

  • Tirzepatide weight-loss data: Jastreboff et al., *New England Journal of Medicine*, 2022 (SURMOUNT-1)
  • Semaglutide weight-loss data: Wilding et al., *New England Journal of Medicine*, 2021 (STEP 1)
  • FDA warning letters to compounding telehealth firms, early 2026: FDA.gov official communications
  • Novo Nordisk settlement announcement, March 9 2026: publicly reported in Reuters and *STAT News*
  • LegitScript certification database: LegitScript.com (cert 50087439)

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